| 1. | Chris Wondolowski
San Jose Earthquakes | United States | 27 | 19 |
| | Edson Buddle
LA Galaxy | United States | 29 | 19 |
| 3. | Conor Casey
Colorado Rapids | United States | 29 | 15 |
| | Dwayne De Rosario
Toronto FC | Canada | 32 | 15 |
| 5. | Juan Pablo Angel
New York Red Bulls | Colombia | 35 | 14 |
| | Omar Cummings
Colorado Rapids | Jamaica | 28 | 14 |
| | Sébastien Le Toux
Philadelphia Union | France | 26 | 14 |
| 8. | Álvaro Saborío
Real Salt Lake | Costa Rica | 28 | 12 |
| | Jeff Cunningham
FC Dallas | United States | 34 | 12 |
| 10. | Steve Zakuani
Seattle Sounders FC | Democratic Republic of the Congo | 22 | 11 |
| 11. | David Ferreira
FC Dallas | Colombia | 31 | 10 |
| | Fredy Montero
Seattle Sounders FC | Colombia | 23 | 10 |
| | Kei Kamara
Sporting Kansas City | Sierra Leone | 26 | 10 |
| 14. | Guillermo Barros Schelotto
Columbus Crew SC | Argentina | 37 | 9 |
| | Justin Braun
Chivas USA | United States | 23 | 9 |
| 16. | Brian Ching
Houston Dynamo | United States | 32 | 7 |
| | Chad Barrett
Toronto FC | United States | 25 | 7 |
| | Danny Mwanga
Philadelphia Union | United States | 19 | 7 |
| | Fabián Espíndola
Real Salt Lake | Argentina | 25 | 7 |
| | Javier Morales
Real Salt Lake | Argentina | 30 | 7 |
| | Landon Donovan
LA Galaxy | United States | 28 | 7 |
| | Marco Pappa
Chicago Fire | Guatemala | 23 | 7 |
