| 1. | Denis Bouanga
Los Angeles FC | Gabon | 29 | 25 |
| 2. | Cucho Hernández
Columbus Crew SC | Colombia | 24 | 21 |
| 3. | Luciano Acosta
FC Cincinnati | Argentina | 29 | 20 |
| 4. | Giorgos Giakoumakis
Atlanta United FC | Greece | 29 | 19 |
| 5. | Brian White
Vancouver Whitecaps FC | United States | 27 | 16 |
| 6. | Daniel Gazdag
Philadelphia Union | Hungary | 27 | 15 |
| | Hany Mukhtar
Nashville SC | Germany | 28 | 15 |
| 8. | Alan Pulido
Sporting Kansas City | Mexico | 32 | 14 |
| | Christian Benteke
D.C. United | Belgium | 33 | 14 |
| | Facundo Torres
Orlando City SC | Uruguay | 23 | 14 |
| | Julian Carranza
Philadelphia Union | Argentina | 23 | 14 |
| 12. | Amine Bassi
Houston Dynamo | Morocco | 26 | 13 |
| | Cristian Espinoza
San Jose Earthquakes | Argentina | 28 | 13 |
| | Duncan McGuire
Orlando City SC | United States | 22 | 13 |
| | Jesus Ferreira
FC Dallas | Colombia | 22 | 13 |
| | Jordan Morris
Seattle Sounders FC | United States | 29 | 13 |
| 17. | Karol Swiderski
Charlotte FC | Poland | 26 | 12 |
| | Thiago Almada
Atlanta United FC | Argentina | 22 | 12 |
| 19. | Carles Gil
New England Revolution | Spain | 31 | 11 |
| | Ryan Gauld
Vancouver Whitecaps FC | Scotland | 27 | 11 |
| | Sebastián Driussi
Austin FC | Argentina | 27 | 11 |
| 22. | Brandon Vázquez
FC Cincinnati | United States | 25 | 10 |
| | Christian Ramirez
Columbus Crew SC | United States | 32 | 10 |
| | Daniel Salloi
Sporting Kansas City | Hungary | 27 | 10 |
| | Jeremy Ebobisse
San Jose Earthquakes | United States | 26 | 10 |
| | Klauss
St. Louis City SC | Brazil | 26 | 10 |
| | Lucas Zelarayán
Columbus Crew SC | Argentina | 31 | 10 |
| | Mikael Uhre
Philadelphia Union | Denmark | 29 | 10 |
| | Nicholas Gioacchini
St. Louis City SC | United States | 23 | 10 |
| | Teemu Pukki
Minnesota United FC | Finland | 33 | 10 |
