| Player, Team | League and season | Goals |
|---|---|---|
| Jeremy Márquez Cruz Azul | 2 | |
| Julián Quiñones Al-Qadsiah FC | 33 | |
| Henry Martín América | 14 | |
| Carlos Vela LA Galaxy/Los Angeles FC | 36 | |
| Hugo Sánchez Real Madrid | 38 |
