| 1. | Carlos Vela
Los Angeles FC/LA Galaxy | Mexico | 30 | 36 |
| 2. | Zlatan Ibrahimovic
LA Galaxy | Sweden | 38 | 32 |
| 3. | Josef Martinez
Atlanta United FC | Venezuela | 26 | 28 |
| 4. | Diego Rossi
Los Angeles FC | Uruguay | 21 | 18 |
| 5. | Chris Wondolowski
San Jose Earthquakes | United States | 36 | 15 |
| | Heber
New York City FC | Brazil | 28 | 15 |
| | Kacper Przybylko
Philadelphia Union | Poland | 26 | 15 |
| | Raul Ruidiaz
Seattle Sounders FC | Peru | 29 | 15 |
| 9. | Alejandro Pozuelo
Toronto FC | Spain | 28 | 14 |
| | Kei Kamara
Colorado Rapids | Sierra Leone | 35 | 14 |
| 11. | CJ Sapong
Chicago Fire | United States | 30 | 13 |
| | Gyasi Zardes
Columbus Crew SC | United States | 28 | 13 |
| | Jordan Morris
Seattle Sounders FC | United States | 25 | 13 |
| | Mauro Manotas
Houston Dynamo | Colombia | 24 | 13 |
| 15. | Alexandru Mitrita
New York City FC | Romania | 24 | 12 |
| | Felipe Gutiérrez
Sporting Kansas City | Chile | 29 | 12 |
| | Jozy Altidore
Toronto FC | United States | 30 | 12 |
| | Nani
Orlando City SC | Portugal | 33 | 12 |
| | Nemanja Nikolic
Chicago Fire | Hungary | 31 | 12 |
| 20. | Brian Fernandez
Portland Timbers | Argentina | 25 | 11 |
| | Daniel Royer
New York Red Bulls | Austria | 29 | 11 |
| | Diego Rubio
Colorado Rapids | Chile | - | 11 |
| | Jeremy Ebobisse
Portland Timbers | United States | 22 | 11 |
| | Pedro Santos
Columbus Crew SC | Portugal | 31 | 11 |
| | Valentin Castellanos
New York City FC | Argentina | 21 | 11 |
| | Wayne Rooney
D.C. United | England | 34 | 11 |
