| Cristhian Stuani | Segunda División – 2021/2022 | 24 |
| Darwin Núñez | Primeira Liga – 2021/2022 | 26 |
| Diego Rossi | MLS – 2020 | 14 |
| Jonathan Rodriguez | Liga MX – Torneo Guardianes 2020 | 13 |
| Cristhian Stuani | Segunda División – 2019/2020 | 31 |
| Edinson Cavani | Ligue 1 – 2017/2018 | 28 |
| Edinson Cavani | Ligue 1 – 2016/2017 | 35 |
| Luis Suárez | La Liga – 2015/2016 | 40 |
| Luis Suárez | Premier League – 2013/2014 | 31 |
| Edinson Cavani | Serie A – 2012/2013 | 29 |
| Iván Alonso | Liga MX – 2011/2012 | 25 |
| Diego Forlán | World Cup – 2010 | 5 |
| Luis Suárez | Eredivisie – 2009/2010 | 35 |
| Diego Forlán | La Liga – 2008/2009 | 32 |
| Walter Pandiani | Europa League – 2006/2007 | 11 |
| Diego Forlán | La Liga – 2004/2005 | 25 |
| Richard Núñez | Super League – 2002/2003 | 27 |
| Richard Núñez | Super League – 2001/2002 | 28 |
