| 1. | Mamadou Diallo
Tampa Bay Mutiny | Senegal | 29 | 28 |
| 2. | Ante Razov
Chicago Fire | United States | 26 | 22 |
| 3. | Adolfo Valencia
New York Red Bulls | Colombia | 32 | 20 |
| 4. | Clint Mathis
New York Red Bulls/LA Galaxy | United States | 23 | 19 |
| 5. | Miklos Molnar
Sporting Kansas City | Denmark | 30 | 17 |
| 6. | Diego Serna
Miami Fusion | Colombia | 26 | 16 |
| | Wolde Harris
New England Revolution | Jamaica | 26 | 16 |
| 8. | Ariel Graziani
FC Dallas | Ecuador | 29 | 15 |
| | Dante Washington
Columbus Crew SC | United States | 29 | 15 |
| 10. | Alex Comas
New York Red Bulls | Colombia | 28 | 13 |
| | Dema Kovalenko
Chicago Fire | United States | 23 | 13 |
| | Hristo Stoichkov
Chicago Fire | Bulgaria | 34 | 13 |
| 13. | Jaime Moreno
D.C. United | Bolivia | 26 | 12 |
| 14. | Jason Kreis
FC Dallas | United States | 27 | 11 |
| 15. | Chris Henderson
Sporting Kansas City | United States | 29 | 10 |
| | Junior Agogo
Colorado Rapids/Chicago Fire | Ghana | 21 | 10 |
| 17. | Cobi Jones
LA Galaxy | United States | 30 | 9 |
| | Imad Baba
New England Revolution | United States | 26 | 9 |
| | Paul Bravo
Colorado Rapids | United States | 32 | 9 |
| | Raúl Díaz Arce
D.C. United/Tampa Bay Mutiny | El Salvador | 30 | 9 |
| 21. | Abdul Thompson Conteh
San Jose Earthquakes | Sierra Leone | 30 | 8 |
| | Manny Lagos
Tampa Bay Mutiny | United States | 29 | 8 |
| | Roy Lassiter
Miami Fusion | United States | 31 | 8 |
| 24. | Josh Wolff
Chicago Fire | United States | 23 | 7 |
