| 1. | Alex Pineda Chacón
Miami Fusion | Honduras | 31 | 20 |
| 2. | Diego Serna
Miami Fusion | Colombia | 27 | 15 |
| 3. | Abdul Thompson Conteh
D.C. United | Sierra Leone | 31 | 14 |
| | John Spencer
Colorado Rapids | Scotland | 31 | 14 |
| 5. | Ronald Cerritos
San Jose Earthquakes | El Salvador | 26 | 12 |
| 6. | Ariel Graziani
FC Dallas | Ecuador | 30 | 11 |
| 7. | Eric Wynalda
Chicago Fire/New England Revolution | United States | 32 | 10 |
| | Jeff Cunningham
Columbus Crew SC | United States | 25 | 10 |
| 9. | Jaime Moreno
D.C. United | Bolivia | 27 | 9 |
| | Mamadou Diallo
Tampa Bay Mutiny | Senegal | 30 | 9 |
| 11. | Brian Maisonneuve
Columbus Crew SC | United States | 28 | 8 |
| | Cate
New England Revolution | Brazil | 27 | 8 |
| | Dema Kovalenko
Chicago Fire | United States | 24 | 8 |
| | John Wilmar Pérez
Columbus Crew SC | Colombia | 31 | 8 |
| | Luis Hernandez
LA Galaxy | Mexico | 32 | 8 |
| | Manny Lagos
San Jose Earthquakes | United States | 30 | 8 |
| | Preki
Miami Fusion | United States | 38 | 8 |
| | Rodrigo Faria
New York Red Bulls | Brazil | 24 | 8 |
| 19. | Clint Mathis
New York Red Bulls | United States | 24 | 7 |
| | Dante Washington
Columbus Crew SC | United States | 30 | 7 |
| | Jason Kreis
FC Dallas | United States | 28 | 7 |
| | Landon Donovan
San Jose Earthquakes | United States | 19 | 7 |
| | Roy Lassiter
Sporting Kansas City | United States | 32 | 7 |
| | Sasha Victorine
LA Galaxy | United States | 23 | 7 |
| | Steve Ralston
Tampa Bay Mutiny | United States | 27 | 7 |
