| 1. | Carlos Ruiz
LA Galaxy | Guatemala | 23 | 24 |
| 2. | Taylor Twellman
New England Revolution | United States | 22 | 23 |
| 3. | Jeff Cunningham
Columbus Crew SC | United States | 26 | 16 |
| 4. | Ante Razov
Chicago Fire | United States | 28 | 14 |
| | Ariel Graziani
San Jose Earthquakes | Ecuador | 31 | 14 |
| | Jason Kreis
FC Dallas | United States | 29 | 14 |
| 7. | Mamadou Diallo
New York Red Bulls | Senegal | 31 | 12 |
| | Rodrigo Faria
New York Red Bulls | Brazil | 25 | 12 |
| 9. | Chris Carrieri
Colorado Rapids | United States | 22 | 11 |
| | Chris Henderson
Colorado Rapids | United States | 31 | 11 |
| | Mark Chung
Colorado Rapids | United States | 32 | 11 |
| 12. | Edson Buddle
Columbus Crew SC | United States | 21 | 9 |
| 13. | Bobby Rhine
FC Dallas | United States | 26 | 8 |
| 14. | Chris Klein
Sporting Kansas City | United States | 26 | 7 |
| | Dante Washington
Columbus Crew SC | United States | 31 | 7 |
| | Darío Fabbro
Sporting Kansas City | Argentina | 26 | 7 |
| | Landon Donovan
San Jose Earthquakes | United States | 20 | 7 |
| | Preki
Sporting Kansas City | United States | 39 | 7 |
| 19. | Ronnie Ekelund
San Jose Earthquakes | Denmark | 30 | 6 |
| 20. | Ali Curtis
D.C. United | United States | 23 | 5 |
| | Bobby Convey
D.C. United | United States | 19 | 5 |
| | Brian McBride
Columbus Crew SC | United States | 30 | 5 |
| | Igor Simutenkov
Sporting Kansas City | Russia | 29 | 5 |
| | John Spencer
Colorado Rapids | Scotland | 32 | 5 |
| | Josh Wolff
Chicago Fire | United States | 25 | 5 |
| | Steve Ralston
New England Revolution | United States | 28 | 5 |
