| 1. | Carlos Ruiz
LA Galaxy | Guatemala | 24 | 17 |
| 2. | Ante Razov
Chicago Fire | United States | 29 | 16 |
| | Landon Donovan
San Jose Earthquakes | United States | 21 | 16 |
| 4. | Taylor Twellman
New England Revolution | United States | 23 | 15 |
| 5. | John Spencer
Colorado Rapids | Scotland | 33 | 14 |
| 6. | Brian McBride
Columbus Crew SC | United States | 31 | 12 |
| | Damani Ralph
Chicago Fire | Jamaica | 23 | 12 |
| | Pat Noonan
New England Revolution | United States | 23 | 12 |
| | Preki
Sporting Kansas City | United States | 40 | 12 |
| 10. | Mark Chung
Colorado Rapids | United States | 33 | 11 |
| 11. | Edson Buddle
Columbus Crew SC | United States | 22 | 10 |
| 12. | Clint Mathis
New York Red Bulls | United States | 26 | 9 |
| | Igor Simutenkov
Sporting Kansas City | Russia | 30 | 9 |
| 14. | Chris Klein
Sporting Kansas City | United States | 27 | 8 |
| | DaMarcus Beasley
Chicago Fire | United States | 21 | 8 |
| 16. | Brian Mullan
San Jose Earthquakes | United States | 25 | 7 |
| | Jason Kreis
FC Dallas | United States | 30 | 7 |
| | Mike Magee
New York Red Bulls | United States | 19 | 7 |
| 19. | Alejandro Moreno
LA Galaxy | Venezuela | 24 | 6 |
| | Brad Davis
FC Dallas | United States | 22 | 6 |
| | Brian Ching
San Jose Earthquakes | United States | 25 | 6 |
| | Brian Kamler
New England Revolution | United States | 31 | 6 |
| | Dema Kovalenko
D.C. United | United States | 26 | 6 |
| | Marco Etcheverry
D.C. United | Bolivia | 33 | 6 |
