| 1. | Christian Gómez
D.C. United | Argentina | 32 | 16 |
| | Jeff Cunningham
Real Salt Lake | United States | 30 | 16 |
| 3. | Ante Razov
Chivas USA | United States | 32 | 15 |
| | Carlos Ruiz
FC Dallas | Guatemala | 27 | 15 |
| 5. | Brian Ching
Houston Dynamo | United States | 28 | 14 |
| | Taylor Twellman
New England Revolution | United States | 26 | 14 |
| 7. | Landon Donovan
LA Galaxy | United States | 24 | 12 |
| 8. | Dwayne De Rosario
Houston Dynamo | Canada | 28 | 11 |
| | Jaime Moreno
D.C. United | Bolivia | 32 | 11 |
| | Kenny Cooper
FC Dallas | United States | 22 | 11 |
| 11. | Scott Sealy
Sporting Kansas City | Trinidad and Tobago | 25 | 10 |
| 12. | Andy Herron
Chicago Fire | Costa Rica | 28 | 9 |
| | Nate Jaqua
Chicago Fire | United States | 25 | 9 |
| | Nicolás Hernández
Colorado Rapids | Argentina | 27 | 9 |
| 15. | Amado Guevara
New York Red Bulls | Honduras | 30 | 8 |
| | Clint Dempsey
New England Revolution | United States | 23 | 8 |
| | Jason Kreis
Real Salt Lake | United States | 33 | 8 |
| | José Burciaga Jr
Sporting Kansas City | United States | 24 | 8 |
| | Juan Pablo García
Chivas USA | Mexico | 24 | 8 |
| 20. | Alecko Eskandarian
D.C. United | United States | 24 | 7 |
| | Chris Klein
Real Salt Lake | United States | 30 | 7 |
| | Chris Rolfe
Chicago Fire | United States | 23 | 7 |
| | Kyle Beckerman
Colorado Rapids | United States | 24 | 7 |
