| 1. | Luciano Emílio
D.C. United | Brazil | 28 | 20 |
| 2. | Juan Pablo Angel
New York Red Bulls | Colombia | 32 | 19 |
| | Taylor Twellman
New England Revolution | United States | 27 | 19 |
| 4. | Eddie Johnson
Sporting Kansas City | United States | 23 | 15 |
| 5. | Maykel Galindo
Chivas USA | Cuba | 26 | 12 |
| 6. | Ante Razov
Chivas USA | United States | 33 | 11 |
| | Christian Gómez
D.C. United | Argentina | 33 | 11 |
| 8. | Brian Ching
Houston Dynamo | United States | 29 | 9 |
| | Jozy Altidore
Toronto FC | United States | 18 | 9 |
| 10. | Carlos Ruiz
FC Dallas | Guatemala | 28 | 8 |
| | Chad Barrett
Chicago Fire | United States | 22 | 8 |
| | Chris Rolfe
Chicago Fire | United States | 24 | 8 |
| | Dwayne De Rosario
Houston Dynamo | Canada | 29 | 8 |
| | Joseph Ngwenya
Columbus Crew SC/Houston Dynamo | Zimbabwe | 26 | 8 |
| | Landon Donovan
LA Galaxy | United States | 25 | 8 |
| | Nate Jaqua
Houston Dynamo/LA Galaxy | United States | 26 | 8 |
| | Robbie Findley
LA Galaxy/Real Salt Lake | United States | 22 | 8 |
| 18. | Alejandro Moreno
Columbus Crew SC/Houston Dynamo | Venezuela | 28 | 7 |
| | Andy Dorman
New England Revolution | Wales | 25 | 7 |
| | Ben Olsen
D.C. United | United States | 30 | 7 |
| | Fred
D.C. United | Brazil | 28 | 7 |
| | Jaime Moreno
D.C. United | Bolivia | 33 | 7 |
| | Pat Noonan
New England Revolution | United States | 27 | 7 |
| | Scott Sealy
Sporting Kansas City | Trinidad and Tobago | 26 | 7 |
