| 1. | Landon Donovan
LA Galaxy | United States | 26 | 20 |
| 2. | Kenny Cooper
FC Dallas | United States | 24 | 18 |
| 3. | Juan Pablo Angel
New York Red Bulls | Colombia | 33 | 16 |
| 4. | Edson Buddle
LA Galaxy | United States | 27 | 15 |
| 5. | Brian Ching
Houston Dynamo | United States | 30 | 13 |
| 6. | Conor Casey
Colorado Rapids | United States | 27 | 11 |
| | Luciano Emílio
D.C. United | Brazil | 29 | 11 |
| 8. | Alejandro Moreno
Columbus Crew SC | Venezuela | 29 | 10 |
| | Chris Rolfe
Chicago Fire | United States | 25 | 10 |
| | Jaime Moreno
D.C. United | Bolivia | 34 | 10 |
| 11. | Chad Barrett
Chicago Fire/Toronto FC | United States | 23 | 9 |
| 12. | Dave van den Bergh
New York Red Bulls | Netherlands | 32 | 8 |
| | Davy Arnaud
Sporting Kansas City | United States | 28 | 8 |
| | Jeff Cunningham
FC Dallas/Toronto FC | United States | 32 | 8 |
| | Steve Ralston
New England Revolution | United States | 34 | 8 |
| | Taylor Twellman
New England Revolution | United States | 28 | 8 |
| | Yura Movsisyan
Real Salt Lake | Armenia | 21 | 8 |
| 18. | Cuauhtémoc Blanco
Chicago Fire | Mexico | 35 | 7 |
| | Dwayne De Rosario
Houston Dynamo | Canada | 30 | 7 |
| | Guillermo Barros Schelotto
Columbus Crew SC | Argentina | 35 | 7 |
| | Javier Morales
Real Salt Lake | Argentina | 28 | 7 |
| | Robbie Rogers
Columbus Crew SC | United States | 21 | 7 |
