| 1. | Chris Wondolowski
San Jose Earthquakes | United States | 29 | 27 |
| 2. | Robbie Keane
LA Galaxy | Ireland | 32 | 22 |
| 3. | Kenny Cooper
New York Red Bulls | United States | 28 | 18 |
| 4. | Álvaro Saborío
Real Salt Lake | Costa Rica | 30 | 17 |
| 5. | Will Bruin
Houston Dynamo | United States | 23 | 16 |
| 6. | Eddie Johnson
Seattle Sounders FC | United States | 28 | 15 |
| | Thierry Henry
New York Red Bulls | France | 35 | 15 |
| 8. | Alan Gordon
San Jose Earthquakes | United States | 31 | 14 |
| 9. | Fredy Montero
Seattle Sounders FC | Colombia | 25 | 13 |
| 10. | Chris Pontius
D.C. United | United States | 25 | 12 |
| 11. | Kei Kamara
Sporting Kansas City | Sierra Leone | 28 | 11 |
| | Landon Donovan
LA Galaxy | United States | 30 | 11 |
| | Saër Sène
New England Revolution | France | 26 | 11 |
| 14. | Steven Lenhart
San Jose Earthquakes | United States | 26 | 10 |
| 15. | Blas Pérez
FC Dallas | Panama | 31 | 9 |
| | CJ Sapong
Sporting Kansas City | United States | 23 | 9 |
| | Danny Koevermans
Toronto FC | Netherlands | 34 | 9 |
| | Eddie Gaven
Columbus Crew SC | United States | 26 | 9 |
| | Fabián Espíndola
Real Salt Lake | Argentina | 27 | 9 |
| | Jairo Arrieta
Columbus Crew SC | Costa Rica | 29 | 9 |
| | Patrice Bernier
CF Montréal | Canada | 33 | 9 |
