| 1. | Camilo Sanvezzo
Vancouver Whitecaps FC | Brazil | 25 | 22 |
| 2. | Mike Magee
Chicago Fire/LA Galaxy | United States | 29 | 21 |
| 3. | Marco Di Vaio
CF Montréal | Italy | 37 | 20 |
| 4. | Robbie Keane
LA Galaxy | Ireland | 33 | 16 |
| 5. | Álvaro Saborío
Real Salt Lake | Costa Rica | 31 | 13 |
| | Diego Fagundez
New England Revolution | Uruguay | 18 | 13 |
| | Dominic Oduro
Columbus Crew SC | Ghana | 28 | 13 |
| 8. | Jack McInerney
Philadelphia Union | United States | 21 | 12 |
| | Tim Cahill
New York Red Bulls | Australia | 34 | 12 |
| 10. | Blas Pérez
FC Dallas | Panama | 32 | 11 |
| | Chris Wondolowski
San Jose Earthquakes | United States | 30 | 11 |
| | Claudio Bieler
Sporting Kansas City | Argentina | 29 | 11 |
| | Diego Valeri
Portland Timbers | Argentina | 27 | 11 |
| | Eddie Johnson
Seattle Sounders FC | United States | 29 | 11 |
| | Federico Higuain
Columbus Crew SC | Argentina | 29 | 11 |
| | Will Johnson
Portland Timbers | Canada | 26 | 11 |
| 17. | Conor Casey
Philadelphia Union | United States | 32 | 10 |
| | Darlington Nagbe
Portland Timbers | United States | 23 | 10 |
| | Deshorn Brown
Colorado Rapids | Jamaica | 22 | 10 |
| | Landon Donovan
LA Galaxy | United States | 31 | 10 |
| | Ryan Johnson
Portland Timbers | Jamaica | 29 | 10 |
| | Thierry Henry
New York Red Bulls | France | 36 | 10 |
| | Will Bruin
Houston Dynamo | United States | 24 | 10 |
