| 1. | Kei Kamara
Columbus Crew SC | Sierra Leone | 31 | 26 |
| 2. | Sebastian Giovinco
Toronto FC | Italy | 28 | 22 |
| 3. | Robbie Keane
LA Galaxy | Ireland | 35 | 20 |
| 4. | Bradley Wright-Phillips
New York Red Bulls | England | 30 | 18 |
| | David Villa
New York City FC | Spain | 34 | 18 |
| | Fanendo Adi
Portland Timbers | Nigeria | 25 | 18 |
| 7. | Cyle Larin
Orlando City SC | Canada | 20 | 17 |
| 8. | Chris Wondolowski
San Jose Earthquakes | United States | 32 | 16 |
| 9. | Obafemi Martins
Seattle Sounders FC | Nigeria | 31 | 15 |
| 10. | Ethan Finlay
Columbus Crew SC | United States | 25 | 13 |
| | Jozy Altidore
Toronto FC | United States | 26 | 13 |
| 12. | Clint Dempsey
Seattle Sounders FC | United States | 32 | 12 |
| | Didier Drogba
CF Montréal | Ivory Coast | 37 | 12 |
| | Dom Dwyer
Sporting Kansas City | United States | 25 | 12 |
| 15. | Chris Rolfe
D.C. United | United States | 32 | 11 |
| | Krisztián Németh
Sporting Kansas City | Hungary | 26 | 11 |
| | Will Bruin
Houston Dynamo | United States | 26 | 11 |
| 18. | Benny Feilhaber
Sporting Kansas City | United States | 30 | 10 |
| | Charlie Davies
New England Revolution | United States | 29 | 10 |
| | David Accam
Chicago Fire | Ghana | 25 | 10 |
| | Fabián Castillo
FC Dallas | Colombia | 23 | 10 |
| | Ignacio Piatti
CF Montréal | Argentina | 30 | 10 |
| | Lloyd Sam
New York Red Bulls | Ghana | 31 | 10 |
| | Octavio Rivero
Vancouver Whitecaps FC | Uruguay | 23 | 10 |
