| 1. | Sebastián Driussi
Austin FC | Argentina | 26 | 26 |
| 2. | Daniel Gazdag
Philadelphia Union | Hungary | 26 | 24 |
| 3. | Hany Mukhtar
Nashville SC | Germany | 27 | 23 |
| 4. | Brandon Vázquez
FC Cincinnati | United States | 24 | 19 |
| | Jesus Ferreira
FC Dallas | Colombia | 21 | 19 |
| 6. | Brenner
FC Cincinnati | Brazil | 22 | 18 |
| | Cristian Arango
Los Angeles FC | Colombia | 27 | 18 |
| | Javier Hernandez
LA Galaxy | Mexico | 34 | 18 |
| 9. | Jeremy Ebobisse
San Jose Earthquakes | United States | 25 | 17 |
| 10. | Diego Rubio
Colorado Rapids | Chile | - | 16 |
| | Gonzalo Higuaín
Inter Miami | Argentina | 34 | 16 |
| 12. | Julian Carranza
Philadelphia Union | Argentina | 22 | 15 |
| | Lewis Morgan
New York Red Bulls | Scotland | 26 | 15 |
| | Romell Quioto
CF Montréal | Honduras | 31 | 15 |
| 15. | Mikael Uhre
Philadelphia Union | Denmark | 28 | 13 |
| | Sebastián Ferreira
Houston Dynamo | Paraguay | 24 | 13 |
| | Valentin Castellanos
New York City FC | Argentina | 24 | 13 |
| 18. | Carlos Vela
Los Angeles FC | Mexico | 33 | 12 |
| | Dejan Joveljic
LA Galaxy | Serbia | 23 | 12 |
| | Emanuel Reynoso
Minnesota United FC | Argentina | 26 | 12 |
| | Taxiarchis Fountas
D.C. United | Greece | 27 | 12 |
| 22. | Djordje Mihailovic
CF Montréal | United States | 23 | 11 |
| | Ercan Kara
Orlando City SC | Austria | 26 | 11 |
| | Leonardo Campana
Inter Miami | Ecuador | 22 | 11 |
| | Luciano Acosta
FC Cincinnati | Argentina | 28 | 11 |
| | Sergio Cordova
Real Salt Lake | Venezuela | 25 | 11 |
