| 1. | Roman Pavlyuchenko
Spartak Moscow | Russia | 24 | 18 |
| 2. | Jô
CSKA Moscow | Brazil | 19 | 14 |
| 3. | Alejandro Dominguez
Rubin Kazan | Argentina | 25 | 13 |
| | Dmitri Loskov
Lokomotiv Moscow | Russia | 32 | 13 |
| | Pavel Pogrebnyak
Tom Tomsk | Russia | 23 | 13 |
| 6. | Dmitri Kirichenko
FC Moscow | Russia | 29 | 12 |
| | Mikhail Osinov
Rostov | Russia | 31 | 12 |
| 8. | Ivica Olic
CSKA Moscow | Croatia | 27 | 9 |
| | Vágner Love
CSKA Moscow | Brazil | 22 | 9 |
| 10. | Roman Adamov
FC Moscow | Russia | 24 | 8 |
| | Yegor Titov
Spartak Moscow | Russia | 30 | 8 |
| 12. | Aleksei Eremenko
Saturn Ramenskoye | Finland | 23 | 7 |
| | Andrey Arshavin
Zenit St.Petersburg | Russia | 25 | 7 |
| | Derlei
Dynamo Moscow | Brazil | 31 | 7 |
| | Dmitri Sychev
Lokomotiv Moscow | Russia | 23 | 7 |
| | Garry O'Connor
Lokomotiv Moscow | Scotland | 23 | 7 |
| | Marko Topic
Krylia Sovetov | Bosnia and Herzegovina | 30 | 7 |
| | Sergei Semak
FC Moscow | Russia | 30 | 7 |
| 19. | Aleksandr Kerzhakov
Zenit St.Petersburg | Russia | 23 | 6 |
| | Dramane Traoré
Lokomotiv Moscow | Mali | 24 | 6 |
| | Edgaras Cesnauskis
Saturn Ramenskoye | Lithuania | 22 | 6 |
| | Essau Kanyenda
Rostov | Malawi | 24 | 6 |
| | Igor Semshov
Dynamo Moscow | Serbia | 28 | 6 |
| | Maksim Romaschenko
Dynamo Moscow | Belarus | 30 | 6 |
| | Vladimir Bystrov
Spartak Moscow | Russia | 22 | 6 |
| | Yevgeny Savin
Amkar Perm | Russia | 22 | 6 |
